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"target": "Stiripentol", "relation": "GENE_DRUG_ASSOC", "paper_count": 14, "confidence": 0.65, "supporting_papers": [ "pmc_3996127", "pmc_4132437", "pmc_6658850", "pmc_6616248", "pmc_6889285", "pmc_7112984", "pmc_2633044", "pmc_12605728" ], "cross_layer": true }, { "source": "Tuberous Sclerosis Complex", "target": "Phenytoin", "relation": "TREATED_WITH", "paper_count": 13, "confidence": 0.65, "supporting_papers": [ "pmc_1511138", "pmc_2794316", "pmc_4302143", "pmc_7396474", "pmc_3986281", "pmc_1014404", "pmc_6757954", "pmc_2827167" ], "cross_layer": true }, { "source": "Lennox-Gastaut Syndrome", "target": "Seizure Freedom", "relation": "HAS_OUTCOME", "paper_count": 13, "confidence": 0.65, "supporting_papers": [ "pmc_6788437", "pmc_3065368", "pmc_6826633", "pmc_2532866", "pmc_12518173", "pmc_4303987", "pmc_6887830", "pmc_4028380" ], "cross_layer": true }, { "source": "Focal Seizures", "target": "Lamotrigine", "relation": "TREATED_WITH", "paper_count": 13, "confidence": 0.65, "supporting_papers": [ "pmc_12736221", "pmc_12573446", "pmc_6878841", "pmc_6714895", "pmc_1743107", "pmc_3986281", "pmc_12451219", "pmc_6555868" ], "cross_layer": true }, { "source": "Antiseizure Medication", "target": "Carbamazepine", "relation": "TREATED_WITH", "paper_count": 13, "confidence": 0.65, "supporting_papers": [ "pmc_7001112", "pmc_12602949", "pmc_12514366", "pmc_12662108", "pmc_12779323", "pmc_12547185", "pmc_12467979", "pmc_12641818" ], "cross_layer": true }, { "source": "Status Epilepticus", "target": "POLG", "relation": "ASSOCIATED_GENE", "paper_count": 13, "confidence": 0.65, "supporting_papers": [ "pmc_6982635", "pmc_12753963", "pmc_6668504", "pmc_7049803", "pmc_4067597", "pmc_6777445", "pmc_3002542", "pmc_3926348" ], "cross_layer": true }, { "source": "Tonic-Clonic Seizure", "target": "Phenytoin", "relation": "TREATED_WITH", "paper_count": 12, "confidence": 0.65, "supporting_papers": [ "pmc_6720964", "pmc_1342611", "pmc_3311449", "pmc_1014914", "pmc_6824109", "pmc_1737151", "pmc_2764413", "pmc_4295057" ], "cross_layer": true }, { "source": "Myoclonic Seizures", "target": "Lamotrigine", "relation": "TREATED_WITH", "paper_count": 12, "confidence": 0.65, "supporting_papers": [ "pmc_1114575", "pmc_321155", "pmc_2532866", "pmc_2656314", "pmc_4062308", "pmc_1564882", "pmc_2668107", "pmc_6801174" ], "cross_layer": true }, { "source": "Antiseizure", "target": "Clobazam", "relation": "TREATED_WITH", "paper_count": 12, "confidence": 0.65, "supporting_papers": [ "pmc_12716290", "pmc_12528060", "pmc_12555108", "pmc_11609837", "pmc_12417036", "pmc_6888707", "pmc_12779310", "pmc_12611011" ], "cross_layer": true }, { "source": "Status Epilepticus", "target": "SCN8A", "relation": "ASSOCIATED_GENE", "paper_count": 12, "confidence": 0.65, "supporting_papers": [ "pmc_12839103", "pmc_6842408", "pmc_4133991", "pmc_7049815", "pmc_4428397", "pmc_7881804", "pmc_1852436", "pmc_6942885" ], "cross_layer": true }, { "source": "Valproate", "target": "50% Seizure Reduction", "relation": "TREATMENT_OUTCOME", "paper_count": 12, "confidence": 0.65, "supporting_papers": [ "pmc_12716290", "pmc_12768112", "pmc_2654531", "pmc_3002622", "pmc_12550305", "pmc_7137370", "pmc_12497770", "pmc_6979440" ], "cross_layer": true } ], "examples": [ { "label": "Dravet therapy", "query": "Dravet syndrome valproate clobazam SCN1A" }, { "label": "SCN1A safety", "query": "SCN1A carbamazepine lamotrigine phenytoin" }, { "label": "TSC precision medicine", "query": "TSC2 tuberous sclerosis everolimus" }, { "label": "Status epilepticus", "query": "status epilepticus treatment outcome" } ] }